It’s nearly flu season and my wife and I are in a quandary about how to protect our severely allergic son, Graeme. With a normal kid (older than 6 months), the Centers for Disease Control (CDC) recommends the flu shot—with good reason. Each year more than 20,000 kids under 5 are hospitalized due to complications from the flu, according to the CDC.
And Graeme, who has asthma, falls into one of the highest risk groups for flu complications, such as bacterial pneumonia or increased asthma attacks.
But he’s also highly allergic to eggs, which means he isn’t supposed to get the shot. The flu vaccine is grown in fertilized chicken eggs and a tiny bit of egg protein can be left over in the final dose. If you’re severely allergic to eggs, you can suffer a bad reaction to the shot, which is why most allergists and the CDC do not recommend it for anyone with egg allergies. Which leaves us in a pickle.
Graeme’s doctors weren’t much help. His pediatrician said if Graeme didn’t have a reaction last year (he got the shot before he was diagnosed with his sundry allergies and didn’t react), he’d be fine this year. The allergist said no way; it’s too risky. So, I decided to call in more experts.
Not every child’s egg allergy is a problem when it comes to the flu vaccine, says Henry Bernstein, MD, professor of pediatrics at Dartmouth Medical School and a member of the American Academy of Pediatrics’ Committee on Infectious Diseases.
When young children are exposed to eggs, “many of the things we see are less severe or local allergic manifestations,” says Dr. Bernstein. “Those are not contraindications to administering flu vaccine. [But] if somebody’s lips swell or they develop breathing difficulties, that’s much more problematic,” he says, indicating that their risk of having a bad reaction to the vaccine is higher. (Still, he recommends that anyone with concern over any severe egg allergy consult his allergist before getting the vaccine.)
When we scratch-tested Graeme for eggs, his allergist characterized his reaction as severe. So, do we leave him wide open to a flu bug or do we take the chance that he won’t have a dangerous reaction to the vaccine?
Both pediatricians and allergists are wrestling with this question right now. In past studies doctors have shown promise vaccinating children with severe egg allergies agains the flu. Earlier this year, for example, researchers presented the results of two small trials where allergic kids received the flu vaccine under the close supervision of allergists.
In one of the studies published in the Journal of Allergy and Clinical Immunology, doctors at the Montreal Children’s Hospital gave vaccinations to 115 children with egg allergies between 2000 and 2006. Most of the patients had asthma (like my son), and some received the vaccine several times during the period of the study.
None had serious allergic reactions. In some cases, doctors tested the vaccine on the skin of patients to see if a reaction would occur before giving them the vaccine. Some patients were also given the vaccine in multiple, smaller doses timed 30 minutes apart. (At least one children’s hospital has developed similar protocols to desensitize children with egg allergies and safely administer the flu vaccine, but the practice is not common.)
Though the work is promising, the researchers in Montreal say additional study is needed to determine if giving doses of the flu vaccine to kids with egg allergies is safe (despite the opinion of a researcher in the other small study).
Until that work is done, there are other ways to protect a child with egg allergies from the flu, says Tony Fiore, MD, an epidemiologist with the CDC and one of the architects of the flu vaccine.
“Try to cocoon your son by getting everyone around him immunized for the flu,” Dr. Fiore says. “That’s the way we deal with kids under 6 months who can’t get the flu vaccine and are at the highest risk for complications.”
Dr. Bernstein agrees. “If they go to a day care with six other kids, let’s hope the six other kids have gotten the flu vaccine,” he says. “One of the reasons we recommend immunizing young children is because they’re great transmitters of the flu to others who won’t do so well if they get the flu.”
We’ve already had a conversation with our day-care provider and the parents of kids who go there. Hopefully, they will get flu shots. Both my wife and I have already gotten ours. If everyone cooperates, and we limit Graeme’s exposure to other groups, his risk of contracting the flu from one of his handlers goes down substantially.
Everyday steps that help fight flu transmission, like washing hands, will also help Graeme, Dr. Bernstein advises. (Here are more tips on how to steer clear of the flu).
And if those efforts fail…
If Graeme does show signs of the flu, Dr. Fiore says antiviral drugs may help. “At first hint of respiratory illness, get your son tested for the flu,” Dr. Fiore says. “Then get antivirals if need be. For them to be effective, they have to be given in the first two days of illness. So it’s something you have to jump on.”
In rare cases, antivirals can also be given to high-risk kids and adults as a preventive measure, such as when a day care experiences an outbreak or during periods of high flu activity in a community, Dr. Fiore says.
We have our marching orders for this flu season. If things pan out in future flu seasons, there may be a safe way for Graeme to get the flu shot. And there’s a good chance he may grow out of his egg allergy, which would mean we could cross the flu vaccine off our enormous list of parenting concerns.
(PHOTO: GETTY IMAGES)
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